- Schuyler (Population: 5,371)
- Scottsbluff (Population: 14,732)
- Seward (Population: 6,319)
- Shelton (Population: 1,140)
- Sidney (Population: 6,282)
- South Sioux City (Population: 11,925)
- Springfield (Population: 1,450)
- St. Paul (Population: 2,218)
- Stanton (Population: 1,627)
- Stromsburg (Population: 1,232)
- Superior (Population: 2,055)
- Sutherland (Population: 1,129)
- Sutton (Population: 1,447)
- Syracuse (Population: 1,762)
