- Saluda (Population: 3,066)
- Sans Souci (Population: 7,836)
- Saxon (Population: 3,707)
- Seabrook Island (Population: 1,250)
- Seneca (Population: 7,652)
- Seven Oaks (Population: 15,755)
- Shell Point (Population: 2,856)
- Simpsonville (Population: 14,352)
- Slater-Marietta (Population: 2,228)
- Socastee (Population: 14,295)
- South Congaree (Population: 2,266)
- South Sumter (Population: 3,365)
- Southern Shops (Population: 3,707)
- Spartanburg (Population: 39,673)
- Springdale (Population: 2,877)
- St. Andrews (Population: 21,814)
- St. George (Population: 2,092)
- St. Matthews (Population: 2,107)
- St. Stephen (Population: 1,776)
- Stateburg (Population: 1,264)
- Sullivan's Island (Population: 1,911)
- Summerville (Population: 27,752)
- Sumter (Population: 39,643)
- Surfside Beach (Population: 4,425)
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